Histology Course S XI 23 Department of Pathology, University of Zurich Histokurs

S XI 23 choriocarcinoma HE  
  ICD-10: C62.9; ICD-O: 9100/3
 
 


23-year-old male; painless enlargement of the right testicle; beta-HCG markedly elevated, alpha-fetoprotein mildy elevated; gynaecomastia.

Morphology:
- Haemorrhage and necrosis
- (1) malignant synctitiotrophoblast
Plenty of eosinophilic cytoplasm
Many irregular nuclei
Positive for beta-HCG
- (2) malignant cytotrophoblast
Regular, well demarcated nuclei
Light shaded cytoplasm, irregular nuclei