Histology Course S XI 21 Department of Pathology, University of Zurich Histokurs

S XI 21 mixed germ cell tumor HE further information (German) on HiPaKu
  ICD-10: C62.9; ICD-O: 9085/3
 
 


21-year-old male, painless enlargement of the left testicle; beta-HCG and alpha fetoprotein elevated; ultrasound shows inhomogenous picture.

Morphologically:
mixture of embryonal carcinoma and yolk sac tumour. Possible additional component: choriocarcinoma, teratoma (mature and/or immature) and seminoma.

Embryonal carcinoma:
- Architecture: cohesive, epithelial arranged cells; solid glandular, papillary structures
- Cytology: large primitive, anaplastic cells, mostly basophilic cytoplasm, pleomorphic overlapping nuclei, numerous mitoses, positive for cytokeratin

Teratoma:
section of derivatives of all three germ layers (glands, skin, cartilage, bone, nervous system, etc), mostly presenting as cysts
- The mature teratoma contains fully differentiated tissue.
- Immature teratoma tissue is differentiated on an embryonal or foetal level.

Yolk sac tumour
- Various patterns in growth (11 in total)
- Mostly microcystic growth with honeycomb/reticular pattern
- Schiller-Duval-Bodies (gomeruloid structure with fibrovascular nucleus surrounded by pleomorphic cuboid cells) are considered pathognomonic.
- Yolk sac tumours stain positive for alpha fetoprotein.