Histology Course S XI 20 Department of Pathology, University of Zurich Histokurs

S XI 20 seminoma HE further information (German) on HiPaKu
  ICD-10: C62.9; ICD-O: 9061/3
 
 


38-year-old male; painless enlargement of the left testicle; tumour markers unremarkable; ultrasound shows homogenous picture.

Morphology:

Seminoma
- Septated tumour cells
- Large round tumour cells showing the following:
Light shaded PAS positive cytoplasm (glycogen)
Coarse Chromatin
Distinct nucleoli
Positive for placental alkalising phosphatase (PLAP)
- Interspersed lymphocytes/plasma cells

Intratubular germ cell neoplasia in neighbouring seminiferous tubules
- Disturbed spermatogenesis
- Enlarged germ cells (compared to seminoma cells)