Histology Course S X 6 Department of Pathology, University of Zurich Histology Course

S X 6 follicular thyroid carcinoma  HE further information (German) on HiPaKu
  ICD-10: C73.9; ICD-O:8330/3
 
 


54-year-old female with small goitre for many years,  a palpable nodule on the left side was noticed a year ago and  slowly increasing in size and cosmetically disturbing; the nodule is mobile, and the patient has no breathing difficulties.

Ultrasound reveals a thyroidal node.

Scintigraphy: so called “cold” node

- Fine needle biopsy: cells of a highly differentiated, partly oncoyctic thyroidal tumor. Dignity not determinable. Partial thyroidectomy.

Macroscopically:
partiallly resected thyroid gland with node, diameter 3.4 cm, distinct capsule. No macroscopic disintegration of capsule.

Microscopically:
- Compact tumour tissue,  trabecular structure in some areas
- Cell strands partly solid, partly with microfollicles
- Mild cellular and nuclear pleomorphism
- Scarce mitoses
- Invasion of the tumor capsule
- Venous invasion

This tumour spreads haematogenously.