Histology Course S X 4 Department of Pathology, University of Zurich Histology Course

S X 4 subacute, not purulent, granulomatous thyroiditis (de Quervain)  HE further information (German) on HiPaKu
  ICD-10: E06.1

46-year-old female suffering from Sore throat and pyrexia. Partial resection of a unilaterally enlarged thyroid gland.

- The thyroid gland parenchyma is partly intact with signs of hyperstimulation, and also contains focally destroyed and scarred areas.
- The follicular epithelium is destroyed and infiltrated by lymphocytes, plasma cells and histiocytes.
- The inflammation has a granulomatous aspect with histiocytes and histiocytic giant cells, some of which contain colloid.
- Fibrosis

As this type of thyroiditis commonly only affects (and destroys) parts of the thyroid gland, hypothyroidism rarely occurs as a consequence; temporary hypothyroidism is possible. The disease usually heals spontaneously within a few months.