Histology Course S X 11 Department of Pathology, University of Zurich Histology Course

S X 11 pheochromocytoma of the adrenal gland  HE further information (German) on HiPaKu
  ICD-10: C74.9; ICD-O: 8700/0
 
 


33-year-old female, removal of the adrenal gland 4 years ago  due to phaechromocytoma. In the preceding months increasing, initially sporadic, later constant headaches; hypertension, adrenaline in 24 hour urine 860 nmol (N<295)

A CT scan showed a tumour of the left adrenal gland, probably phaechromocytoma
Macroscopically: specimen of the right adrenal gland, 47g, with soft tumour, diameter 5 cm, cut surface grey; brown when exposed to air, partly haemorrhagic.
5 months later a thyroidectomy was performed due to massively increased plasma calcitonin levels.

Microscopically:
- Section of tumour, partly covered by adrenal gland.
- The tumor is made up of segments containing  tumour tissue similar to alveolae in structure and broad separating septa, some along vessels.
- The tumour cells appear polymorphous with partly very large cells¸ and nuclear polymorphism.
- Few mitoses