Histology Course S VIII 7 Departement of Pathology, University of Zurich Histokurs

S VIII 7 amyloidosis, kidney Kongorot further information (German) on HiPaKu
  ICD-10: E85.4
 
 


70-year-old female with nephrotic syndrome, burnt out chronic polyarthritis, autopsy specimen

- The glomeruli contain a red-staining amyloid in the capillary slings with irregular deposits in the area of the basal membrane as well as the mesangium
- In final stages, the glomerular structure is destroyed.
- The small arteries and arterioles contain homgenous amyloid deposits.

Immunohistochemistry: t In 90% of cases, amyloidosis in the kidney is usually of the AL-type.

Aetiology: Most commonly paraproteinaemia (e.g plasmacytoma). Chronic infection may also cause amyloidosis (AA-amyloidosis, serum-amyloid associated protein)
The congo red staining can be confirmed by green polarized light.


 
  Aufnahme mit polarisiertem Licht (Mikroskopaufbau):

Die Kongorotbindung lässt sich durch die mikroskopische Durchlichtaufnahme und die grüne Doppelbrechung in polarisiertem Licht nachweisen: