Histology Course S VIII 5 Departement of Pathology, University of Zurich Histokurs

S VIII 5 kidney with disseminated intravascular coagulation PM further information (German) on HiPaKu
  ICD-10: D65

35-year-old male, with polytrauma and shock, dies as an organ donor. The given specimen depicts one macroscopically unremarkable kidney which was transplanted. The other kidney is transplanted but does not gain normal function in the recipient.

- Multiple microthrombi, especially visible in the glomerular capillary slings. The peritubular vessels are heavily congested.

Pathogenesis: In complicated or primary septic shock, the intravascular coagulation can lead to acute renal failure. Various other causes often show less extensive microthrombosis with a less dramatic clinical course. All forms can morphologically be summarised as thrombotic microagiopathy (which clinically sometimes manifests itself as intravascular coagulation or microangiopathic haemolytic anaemia of various aetiology)