Histology Course S VIII 11 Departement of Pathology, University of Zurich Histokurs

S VIII 11 reflux nephropathy HE  
  ICD-10: Q62.7
 
 


15-year-old boy with terminal renal failure, left nephrectomy for transplantation

- The section shows a pole of the kidney which is atrophic in its major segment. The cut middle sections of the kidney are unchanged.
- The affected tubuli are massively atrophic and show pseudostruminiform changes .
- The interstitium contains clusters of chronic inflammation.
- The arteries show an adaptive fibrosis of the intima.
- The glomeruli are situated next to each other and completely sclerosed (this finding is part of the secondary vascular scar formation)
- The renal pelvis is dilated.

Pathogenesis:
Reflux leads to a lesion of the kidney characteristically accentuated at the pole. This damage consists of atrophy with chronic interstitial and/or pyelonephritic changes as well as secondary vascular scars. The given example also shows dysplastic lesions of the medulla caused by drainage problems in utero.