Histology Course S VII 6 Department of Pathology, University of Zurich histologycourse

S VII 6 Kongophile Angiopathie mit Status cribrosus HE  
  congophilic angiopathy with cribriform state ICD-10: E85.4+ I68.0

82-year-old female with dementia.

- The cortex contains numerous vessels with thickened walls. There is immunohistochemical evidence of amyloidosis as well as positive  congo red staining (polarised light). Numerous vessels in the subarachnoidal space also contain amyloid deposits.
- Vessels with amyloid deposition appear to be split (vessel within a vessel).
- Some perivascular spaces in the subcortical white matter appear enlarged (criblure).
Numerous senile plaques and neurofibrillary degeneration could be shown in the hippocampus and temporal cortex (evidently in combination with Alzheimer`s disease).