Histology Course S VII 23 Department of Pathology, University of Zurich Histology Course

S VII 23 ependymoma HE  
  ICD-10: C71.5; ICD-O: 9391/3

35-year old male. 6 months’ history of recurrent headache. Fundoscopy revealed papillary oedema. The CT scan shows a large tumour in the left lateral ventricle.

- Tumour with moderate cell density. The cells are arranged in a synctitium, i.e the plasma membranes are not recognisable. The nuclei are round to oval with medium chromatin content.
- No mitoses
- Some parts of the tumour are rich in connective tissue fibres.
- Typical architecture :  perivascular spaces without nuclei (so-called pseudorosettes).
- Small calcified islets
WHO grade II