Histology Course S VII 18 Department of Pathology, University of Zurich histologycourse

S VII 18 Gemistozytisches Astrozytom  IHC: GFAP  
  gemistocytic astrocytoma ICD-10: C71.1; ICD-O: 9411/3

45-year-old male, 3-year history of convulsions. 3-month history of mild unilateral symptoms and increased frequency of fits. CT shows large tumour in right frontal lobe.

-  Mostly isomorphous tumour of medium cell density. The majority of tumour cells have a cytoplasmic body with shortened processes which strongly express GFAP. These are gemistocytci; (neoplastic) astrocytes.
- Beside there are small tumour cells without demarcated cytoplasm which do not express GFAP.
- No mitoses. No necrosis. No notable vessel proliferation.
WHO grade II