Histology Course S VII 15 Department of Pathology, University of Zurich histologycourse

S VII 15 Amyotrophe Lateralsklerose, Rückenmark   Luxol-Nissl  
  amyotrophic lateral sclerosis ICD-10: G12.2

55-year-old male, 3-year history of increasing motor weakness with fasciculation and ascending paralysis in terminal stages. Death due to respiratory arrest.

- Almost complete loss of ventral motor neurons

- Extensive (descending) degeneration of pyramidal strands (secondary degeneration after primary damage of Betz giant cells in the paracentral gyrus)