Histology Course S VII 12 Department of Pathology, University of Zurich Histology Course

S VII 12 vacuolated HIV-myelopathy   Luxol-Nissl  
  ICD-10: B23.8

Young patient in ill health with; rapidly progressing sensomotoric tetraparesis. HIV-positive (clinical stage IV).

- Cross-section through cervical cord with noticeably large, optically empty vacuoles in the area of the long tracts
- These vacuoles displace the myelinated fibres.
- The diameter of the vacuoles is up to 80 um
-  The dorsal tracts also show bilateral central subacute demyelination with resorption.
- The grey matter contains well-differentiated ventral motor neurons without remarkable pathological findings.