Histology Course S V 5 Department of Pathology, University of Zurich Histology Course

S V 5 Hodkin's disease, mixed cellularity HE further information (German) on HiPaKu
  ICD-10: C81.2; ICD-O: 9652/3

27-year-old female with painless enlargement of a left supraclavicular lymph node. Excision.

- This lymph node shows the diffuse growth of a multicoloured cell infiltrate.
- Small lymphocytes as well as histiocytes and eosinophilic granulocytes can also be seen.
- There are two diagnostic types of cells for Hodgkin’s disease, namely Sternberg-Reed cells with a large double nucleus and large mirroring nucleoli as well as their mononuclear variation, the Hodgkin cell.

The epidemiological distribution of Hodgkin`s diseaseis bimodal with two peaks, one at age 10-20 and one in individuals aged 50-60.Systemic symptoms often include pyrexia, night sweat, weight loss and pruritus (B-symptoms). The stage at  clinical onset is an important prognostic factor.