30-year-old male with cough, fine reticular lung shadow and enlargement of hilar lymph nodes. Excision of a supraclavicular lymph node.
- Throughout the lymph node, non-caseateing epithelioid cell granulomas without a rim of lymphocytes can be seen.
- Giant cells, partly foreign-body-type, typically in the centre of the granuloma
- Layered calcified bodies (Schaumann bodies) can be found in some of the giant cells.
Note: The morphology of the granuloma points toward a diagnosis of sarcoidosis. Diagnosis can only be made in conjunction with clinical evidence and morphology. It is not possible to distinguish sarcoidosis from tuberculosis without a stain for bacilli.