Histology Course S IX 8 Department of Pathology, University of Zurich Histology Course

S IX 8 osteoarthrosis HE  
  ICD-10: M16.9

65-year-old male with chronic, temporarily severe disabling hip pain and restricted movement. Resection specimen of head of femur.

- Joint cartilage: destruction of varying degree. The surface shows fibrillation over vertical substance tears and (sub)total eburnation. Possible microfractures with the development of pseudocytes.
- Reactive changes of subchondral bone structure :Sclerosis, increased bone remodeling, bone marrow fibrosis and cellular activity (macrophages, possibly FK giant cells)
- Minimal inflammatory infiltration
- The tela synovialis shows signs of chronic irritative synovitis.

Comment: In English a degenerative disease as well as a mainly inflammatory infiltrate, which occurs following a primary inflammatory event, are both termed arthritis. A distinction is not made. In German the former is termed arthrosis.