60-year-old male with chronic renal failure, on dialysis. Death due to heart failure and pneumonia. Autopsy specimen.
- Fibroosteoclasis(also refer to specimen S IX 4): lacunar osteoclastic bone resorption with accompanying fibrosis.
- Increased non-mineralising bone substance in the form of osteoid rims
Comment: the combination of fibroosteoclasis and osteoidosis are the most common forms of morphological changes seen in renal osteopathy. Less commonly seen is either a disturbance in mineralization (osteoidosis) or fibroosteoclasia (due to the secondary hyperparathyroidism).