Histology Course S IX 15 Department of Pathology, University of Zurich Histology Course

S IX 15 myxofibrosarcoma  HE  
  ICD-10: C49.1; ICD-O: 8830/3

67-year-old male, tumourous swelling on thigh

- Pleomorphic tumour tissue of increased perivascular cell density with nodular growth.
- The tumour is made up of spindle cells and multinucleated, partly bizarre giant tumour cells.
- Generally extensive cell and nuclear polymorphism with many atypical mitoses
- The spindle cells form collagenous fibres or excrete a myxoid substance.

Previously known as myxoid malignant fibrous histiocytoma (Myxoid MHF), myxofibrosarcoma is one of the most commonly occurring soft tissue sarcomas in the older patient and is classified as a fibroblastic differentiated neoplasia according the latest WHO classification (WHO 2002).