Histology Course S IV 17 Department of Pathology, University of Zurich Histokurs

S IV 17 large cell lung cancer HE further information (German) on HiPaKu
  ICD-10: C34.9; ICD-O: 8012/3

65-year-old male, an investigation for haemoptysis led to the radiological finding of a lung shadow. Following diagnosis a bronchoscopic biopsy was undertaken: resection. Operative specimen.

- Lung tissue with infiltrative growing tumour
- Strands of epithelial cells of varying breadth
- Medium-sized cells with distinctly visible rim of cytoplasm.
- Polymorphous, bubble-like nuclei with prominent nucleoli
- There is no differentiation of the squamous-cell epithelium (intercellular bridges or keratinsation absent); no glands.

Differential diagnosis: other non-small cell bronchial carcinoma
- Metastases of an extrapulmonary carcinoma