60-year-old male with increasing dyspnoea over the past few years.
Death following right heart failure. Autopsy specimen.
Macroscopically: honeycomb-like changes of the lung, with bumpy
cirrhosis-like surface and increased consistency
- Loss of lung architecture
- The parenchyma is rearranged into numerous cystic cavities and
wide air-filled cavities with thick septa, lined by cuboid and cylindrical
cells, some ciliated.
- Collagen fibres in the septa, clusters of smooth muscle cells
- Inflammatory infiltrate, predominantly with lymphocytes and plasma
- Blood vessels, partly with reactive wall thickening
This is a scarred lung in its final stages and no conclusions about
the aetiology can be made.