Histology Course S III 8 Departement of Pathology, University of Zurich Histokurs

S III 8 coronary artery, soft plaque Orcein-Sirius  
  ICD-10: I25.1

70-year.old male with large transmural anterior wall infarction and proximal occlusion of the anterior descending branch. Autopsy specimen.

- Cross-section of coronaries shows thrombotic occlusion
- Atheroma in intima with areas spared (cholesterol crystals) and foam cells, partly penetrated with blood.
- Layered thrombus partly penetrated with cholesterol and foam cells (ruptured plaque)
- The media is atrophic in parts, whereas the adventitia is widened.