70-year-old female, death due to pulmonary embolism following a
fracture of the femur neck. Low-grade hypertrophy of left ventricle.
Treated hypertension. Stenosing sclerosis of all three coronary
arteries. Autopsy specimen.
Macroscopically: pale inner layer in the left apex.
- Inner layer: small areas where muscle fibres have been replaced
by collagenous connective tissue (old lesion)
- In loose scar tissue: vessels with wide lumen and thin walls (recent
- Irregularly increased interstitial collagen fibres in clusters
- Myocytes are vital but chronically damaged by ischaemia, resulting
in a loss of staining properties of the cytoplasm (tubular myopathy)