Histology Course S III 7 Departement of Pathology, University of Zurich Histokurs

S III 7 myocardial fibrosis van Gieson-Elastin further information (German) on HiPaKu
  ICD-10: I51.4

70-year-old female, death due to pulmonary embolism following a fracture of the femur neck. Low-grade hypertrophy of left ventricle. Treated hypertension. Stenosing sclerosis of all three coronary arteries. Autopsy specimen.

Macroscopically: pale inner layer in the left apex.

- Inner layer: small areas where muscle fibres have been replaced by collagenous connective tissue (old lesion)
- In loose scar tissue: vessels with wide lumen and thin walls (recent lesion)
- Irregularly increased interstitial collagen fibres in clusters
- Myocytes are vital but chronically damaged by ischaemia, resulting in a loss of staining properties of the cytoplasm (tubular myopathy)