Histology Course S III 3 Departement of Pathology, University of Zurich Histokurs

S III 3 amyloidosis of myocard Kongorot further information (German) on HiPaKu
  ICD-10: E85.4† I43.1*
 
 

 
90-year-old female, death due to bronchopneumonia. No known cardiac disease. Autopsy specimen.

Macroscopically: mildly globally enlarged heart, noticeably hard.

- Numerous clusters of variable size all staining congo red found throughout the myocardium.
- Large clusters : homgenous masses staining congo red, replacing muscle fibres
- Small clusters: congo red masses accumulating between muscle fibres and capillaries, extending thus the distance of oxygen diffusion
- Some muscle fibres enclosed by amyloid are significantly smaller (atrophied) than the unaffected neighbouring muscle fibres (compensated hypertrophy)
- Hyaline substance can be found throughout individual intramural branches of coronary arteries (media and intima layer)
- The endocardium is only slightly affected by skip lesions
- In the subpericardial adipose tissue there is only mild amyloid deposition around individual adipocytes.