Histology Course S II 6 Departement of Pathology, University of Zurich Histokurs

S II 6 florid alcoholic hepatitis with mallory bodies CAB further information (German) on HiPaKu
  ICD-10: K70.1 R89.7

41-year-old male, Whisky drinker, blood results: AST 80IU/l, ALT 60IU/l, markedly raised Gamma GT (1032 IU/l, Normal<15), normal ALP (25-85IU/l) Macrocytosis in peripheral blood count. (see specimen SII3 for reference ranges).

- The parenchyma structure is markedly disrupted by portocentral septa which have lead to cirrhotic rearrangement.
- Predominantly large-drop steatosis of the liver (similar to specimen SII5).
- Fibrosis spreads from the centre of the lobes and is the result of necrosis.
- In the centre of the acinus, the hepatocytes are ballooned with Mallory bodies (clumped cytokeratin as a consequence of disorganization of the cytoskeleton)
- Hepatocytes with Mallory bodies with neutrophilic granulocytes
- Extensive mesh fibrosis, especially in the pericentral region
- Rather low-graded proliferation of biliary canals in the portal fields
- Throughout the cirrhosis regeneration (multiple layered hepatocytes) can be found.