41-year-old male, Whisky drinker, blood results: AST 80IU/l, ALT
60IU/l, markedly raised Gamma GT (1032 IU/l, Normal<15), normal
ALP (25-85IU/l) Macrocytosis in peripheral blood count. (see specimen
SII3 for reference ranges).
- The parenchyma structure is markedly disrupted by portocentral
septa which have lead to cirrhotic rearrangement.
- Predominantly large-drop steatosis of the liver (similar to specimen
- Fibrosis spreads from the centre of the lobes and is the result
- In the centre of the acinus, the hepatocytes are ballooned with
Mallory bodies (clumped cytokeratin as a consequence of disorganization
of the cytoskeleton)
- Hepatocytes with Mallory bodies with neutrophilic granulocytes
- Extensive mesh fibrosis, especially in the pericentral region
- Rather low-graded proliferation of biliary canals in the portal
- Throughout the cirrhosis regeneration (multiple layered hepatocytes)
can be found.