Histology Course S II 3 Department of Pathology, University of Zurich histologycourse

S II 3 HBs-Ag positive chronicly active hepatitis Orcein further information (German) on HiPaKu
  ICD-10: B18.1 Z22.5

36-year.old male, Kosovo-Albanian, HBs-antigen positive, Anti-HBc positive, anti-HBe positive
Aspartate aminotransferase (AST=SGOT):80-120 IU/I (normal<40), Alanine-aminotransferase (ALT=SGPT):80-120 IU/I (normal<40)

- Lobal structures disrupted and only partially preserved.
- Portal and periportal fibrosis with porto-portal and individual portocentral septa (bridging necrosis and fibrosis)
- Cluster-like cirrhotic rearrangement with regenerative nodules, which are surrounded by scar-like connective tissue.
- Momentarily mild inflammatory activity : no fresh peace-meal-necrosis
- Plenty of mosaic-like distributed milk glass cells (Shikat cells): cytoplasm stains dark-brown- red with Orcein, sparing the nucleus.

This patient is a surface antigen positive HBV carrier. The milk-glass aspect of the hepatocyte occurs due to the smooth endoplasmic reticulum being filled with HBs antigen.