Histology Course S II 2 Department of Pathology, University of Zurich Histokurs

S II 2 acute viral hepatitis. mouse, LCMV-infection HE further information (German) on HiPaKu

Specimen of murine liver (strain C57BL/6), 7 days after i.v inoculation with LCMV-Docile (Lymphocytic choriomeningitis virus, strain: Docile 2x106 plague forming units)

- Extensive hepatocyte degeneration
- Hepatocyte necrosis
- Individual hepatocytes with eosinophilic degeneration,partially multinucleated
- Abundant inflammatory infiltrates in parenchyma as a reaction of hepatocyte degeneration: lymphocytes, individual neutrophils, Kupffer cells, Stellate cells
- Hypertrophy and hyperplasia of Kupffer cells and Stellate cells
- Infiltration of mononuclear cells (predominantly lymphocytes) in the portal field