Histology Course S II 13 Department of Pathology, University of Zurich Histology Course

S II 13 chronic myelogenous leukemia (CML) with acute blast crisis, liver HE  
  ICD-10: C92.1; ICD-O: 9875/3
 
 

 
ICD-10: C92.1; ICD-O: 9875/3
40-year-old male, increasing anaemia. A bone marrow biopsy shows infiltration of CML. In the peripheral blood release of blasts

- The lobar structure of the liver is maintained.
- Steatosis, predominantly in pericentral zones (as in the given case)
- Portal fields with loosened cellular infiltrates
- Abundant myeloid blasts in the sinuosoids.

In CLL, blasts mainly lie in the portal fields, as opposed to CLL.