Histology Course S II 12 Department of Pathology, University of Zurich Histokurs

S II 12 colon carcinoma, liver metastasis HE  
  ICD-10: C18.9, C78.7; ICD-O: 8140/3, 8140/6

72-year-old male. Painful hepatomegaly after right hemicolectomy for carcinoma (2 years previously)

- Infiltration of moderately differentiated adenocarcinoma
- In contrast to hepatocellular carcinoma, the stroma is fibrous.
- Mucus is located in the lumen of the glands and in the cribriform transformation.
- In the surrounding liver tissue there is no cirrhotic rearrangement and only discretely inflamed infiltration in the portal fields.
- A peritumoural inflammation, reminiscent of chronic active hepatitis, may occur in metastases.
- Circulatory disturbances often occur in the area of the tumour tissue.