Histology Course S II 1 Department of Pathology, University of Zurich Histokurs

S II 1 pericentric shock-induced necrosis HE further information (German) on HiPaKu
  ICD-10: K72.9

70-year-old male with haemorrhagic shock (bleeding duodenal/stress ulcer) after myocardial infarction. Autopsy preparation.

- Massive necrosis of parenchyma (coagulation necrosis with vaguely visible trabecular structure. In contrast, colliquation necrosis leaves an empty mesh.) Usually, a ring of periportal parenchyma remains. (zone 1 of the acinus according to Rappaport).
- In the remaining parenchyma focal steatosis (mainly large drops)
- Loose infiltration with multisegmented leucocytes
- An invasion of macrophages has not yet occurred (recent lesion in contrast to specimen SII 4)

The distribution pattern also occurs in necrosis of the liver due to other causes such as intoxication (e.g Amanita phalloides) or medication in toxic doses (acetaminophen).