Histology Course S I 9 Department of Pathology, University of Zurich Histokurs

S I 9 Whipple's disease, ileum PAS further information (German) on HiPaKu
  ICD-10: K90.8+ M14.8*

50-year-old male suffering from.malabsorption syndrome with diarrhoea, steatorrhoea, abdominal cramps, bloating, fever and weight loss.

- This is a specimen taken at autopsy and contains autolytic changes of the mucosa (the surface epithelium is largely absent).
- The most obvious finding is the high number of macrophages, particularly in the lamina propria, but also in the submucosa and even in the muscularis propria.
- Where the density of macrophages is reduced (especially in the muscle layer) a PAS positive content of finely granular material can be seen. These granules are collections of bacteria like organisms which are longitudinal in shape on electron microscopy.

Whipple`s disease is a systemic disease which, apart from the small bowel, also affects skin, CNS, joints, heart, blood vessels, kidney, lungs, serous membranes , lymph nodes, spleen and the liver.