50-year-old male suffering from.malabsorption syndrome with diarrhoea,
steatorrhoea, abdominal cramps, bloating, fever and weight loss.
- This is a specimen taken at autopsy and contains autolytic changes
of the mucosa (the surface epithelium is largely absent).
- The most obvious finding is the high number of macrophages, particularly
in the lamina propria, but also in the submucosa and even in the
- Where the density of macrophages is reduced (especially in the
muscle layer) a PAS positive content of finely granular material
can be seen. These granules are collections of bacteria like organisms
which are longitudinal in shape on electron microscopy.
Whipple`s disease is a systemic disease which, apart from the small
bowel, also affects skin, CNS, joints, heart, blood vessels, kidney,
lungs, serous membranes , lymph nodes, spleen and the liver.