Histology Course S I 5 Department of Pathology, University of Zurich Histokurs

S I 5 malignant non-Hodgkin's lymphoma HE further information (German) on HiPaKu
  ICD-10: C16.9; ICD-0: 9591/3

50-year-old female with weight loss, loss of appetiteand change in bowel habits. A CT scan reveals fixed, thickened wall of the gastric antrum, no ulcer. Gastric resection (Billroth II).

- Specimen from gastric antrum with moderate chronic gastritis (infiltration of plasma cells in lamina propria). The strong level of activity of this gastritis can be concluded from the presence of plenty of neutrophils (particularly intraepithelial).
- helicobacter only found sparingly (and not the whole specimen)
- On one side of the specimen the mucosa and submucosa are heavily disrupted by an infiltrating tumour
- This infiltrate consists of a loose, non-epithelial group of tumour cells of moderate to large size. These mainly seem to be centroblasts: centroblastic malignant lymphoma. Due to the presence of immunoblasts this tumour is of the "polymorphous subtype".
- The tumour tissue is partially necrotic.

The co-existence of chronic gastritis with gastric lymphoma is probably incidental.