54-year-old male with weight loss, increasing loss of appetite and
anaemia. The CT scan reveals extensive thickening and infiltration
of the gastric antrum. Gastric resection (Billroth II)
- Immunohistochemistry of the specimen shows less contrast compared
to the H&E stain. Shown here is the antral mucosa with underlying
thickened submucosa containing inflammatory infiltration with follicles.
Underneath is the muscularis propria which (alike the thickened
submucosa) is also infiltrated with tumor tissue.
- The tumour consists of individual cells or groups of cells and
does not form glandular strings
- Small groups of tumour cells or individual cells are invading
the pre-existing structures and thus it is not possible to define
a clear border between tumour and normal tissue. Hence the nomenclature
- The antibody LU5 stains with a brown reaction product in epithelial
cells which is nicely shown on the surface epithelium. This antibody
also defines carcinoma cells (epithelial phenotype) and makes these
distinct as such. In an H&E preparation it is diffcult to distinguish
the tumour cells from scar tissue or inflammatory infiltration.