Histology Course S I 28 Department of Pathology, University of Zurich Histokurs

S I 28 ductal carcinoma PAS further information (German) on HiPaKu
  ICD-10: C25.9; ICD-O: 8500/3

70-year-old male with rapid weight loss, epigastric pain, nausea&vomiting, mild icterus. Ultrasound shows a tumour in the area of the pancreatic head.

- Large tumour masses consisting of solid cell groups and tubular structures
- Abundant stroma in which the tumour grows as individual tubules
- Within the tubules and in the tumour cells: PAS-positive material
- Necrosis of the tumour tissue
- The endocrine islands remain intact. The practically inexistent exocrine pancreatic tissue is replaced by fibrosis resulting in obstructive chronic pancreatitis.

The obstructive pancreatitis often occurs as a consequence of the disturbed flow in the pancreatic duct or one of the neighbouring ductules in the head of the pancreas.