Histology Course  Department of Pathology, University of Zurich Histology Course
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General Tumors ICD-Code Scripts (German)

GENERAL PROCEDURE
 
 
MACROSCOPY • shape, size, colour, density, uniformity
• transfer two-dimensional shape of the cut into three-dimensional cut:
   nodes, crumbles, compact parenchyma, hollow organ, inhomogeneous tissue
 
MICROSCOPY  
Magnifying glass • architecture of the tissue, surface
 
Low and medium magnification • comparison of the different parts
• organ diagnosis
 
  Search for the pathological change and its evaluation
• localisation: in whole organ/in part of the organ
• diffuse, focused, knotty
• separation to parenchyma: clear/unclear
• colour, density, abundance of cells
• architecture of the lesion:
   cords, plates, columns, undefinable, irregular
• necrosis: localisation
• granuloma
• pathological depositions
• changes of the extracellular matrix
• changes of vessels, nerves, etc.
• reaction of surrounding tissue: parenchyma, interstitium, vessels, nerves, inflammation
 
DIFFERENTIAL DIAGNOSIS
 
Identification of the type of diagnosis • circulatory disturbance
• inflammation
• immunopathology
• tumor
• physical damage
• chemical damage
• metabolic dysfunction
• malformation
• cellular adaptation
 
High magnification • evaluation of cytological criteria
• intercellular relations: dense/loose arrangement
• cell size, cell type
• mono-/polymorphism
• staining of cytoplasm
• cytoplasmic inclusions
• size and shape of nucleus, arrangement of chromatin
• number of mitosis, typical/atypical mitosis
• stroma: fibrosis, inflammation, no reaction
• type of depositions, localisation
• type of necrosis
• type of changes in vessels
 
 
DIAGNOSIS OR AS MUCH PRECISE AS POSSIBLE DIFFERENTIAL DIAGNOSIS
  
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