50-year-old male suffered from symptoms of increased intracranial pressure, headaches, somnolence and seizures (surgical specimen).
- A section of the cortex and medulla is shown. A circumscribed tumor located mostly in the medulla is seen.
- The tumor displays areas of necroses arranged in a serpentine pattern. In some areas hemorrhage into the tumor is observed.
- Necroses are surrounded by a dense infiltrate of tumor cells forming palisade-like structures (pseudopalisading).
- Neoplastic astrocytes may be highly polymorphic, numerous mitotic figures and tumor giant cells are present.
- Prominent microvascular proliferations are present that appear as the typically described ‘glomeruloid tufts’. The latter consist of multilayered proliferating endothelial cells and smooth muscle cells protruding into the vascular lumen.