Histology Course A IV 58 Department of Pathology, University of Zurich Histokurs

A IV 58 glioblastoma multiforme (astrocytoma grade IV) HE further information (German) on HiPaKu 
  ICD-10: C71.9; ICD-O: 9440/3
50-year-old male suffered from symptoms of increased intracranial pressure, headaches, somnolence and seizures (surgical specimen).
- A section of the cortex and medulla is shown. A circumscribed tumor located mostly in the medulla is seen.
- The tumor displays areas of necroses arranged in a serpentine pattern. In some areas hemorrhage into the tumor is observed.
- Necroses are surrounded by a dense infiltrate of tumor cells forming palisade-like structures (pseudopalisading).
- Neoplastic astrocytes may be highly polymorphic, numerous mitotic figures and tumor giant cells are present.
- Prominent microvascular proliferations are present that appear as the typically described ‘glomeruloid tufts’. The latter consist of multilayered proliferating endothelial cells and smooth muscle cells protruding into the vascular lumen.

The tumor may exhibit focal calcification.