52-year-old female suffered from abnormal vaginal bleeding after sexual intercourse. A Papanicolaou smear revealed the presence of atypical cells. Hysterectomy.
- The cervix is partly destroyed by an poorly differentiated tumor that deeply infiltrates into the stroma. Invasion into lymphatic vessels is present.
- Sheets of tumor cells exhibiting on occasion central keratinization and the presence of intercellular bridges in between tumor cells point to the squamous derivation of this tumor.
- Individual tumor cells exhibit a basophilic cytoplasm. In some parts of the tumor, severe nuclear atypias and a high mitotic count with atypical mitoses are observed.
- The tumor is partly surrounded by a predominantly lymphocytic inflammatory infiltrate.
- Towards the vaginal resection margin the cervix is still covered by an intact layer of squamous epithelium showing prominent parakeratotic keratinization.