Histology Course A IV 42 Department of Pathology, University of Zurich Histokurs

A IV 42

squamous cell carcinoma of the cervix HE  
  ICD-10: C53.9; ICD-O: 8070/3
52-year-old female suffered from abnormal vaginal bleeding after sexual intercourse. A Papanicolaou smear revealed the presence of atypical cells. Hysterectomy.

- The cervix is partly destroyed by an poorly differentiated tumor that deeply infiltrates into the stroma. Invasion into lymphatic vessels is present.
- Sheets of tumor cells exhibiting on occasion central keratinization and the presence of intercellular bridges in between tumor cells point to the squamous derivation of this tumor.
- Individual tumor cells exhibit a basophilic cytoplasm. In some parts of the tumor, severe nuclear atypias and a high mitotic count with atypical mitoses are observed.
- The tumor is partly surrounded by a predominantly lymphocytic inflammatory infiltrate.
- Towards the vaginal resection margin the cervix is still covered by an intact layer of squamous epithelium showing prominent parakeratotic keratinization.

Compare also slides A III 9, A III 19, A IV 41