42-year-old female had cervical conization after detection of atypical cells in a routine Papanicolaou smear.
- Squamous epithelium shows atypia in all cell layers: (1) Lack of maturation. (2) Cells with hyperchromatic enlarged nuclei are found through the entire thickness of the epithelium. (3) Cells exhibit a predominantly basophilic cytoplasm. (4) High frequency of mitotic figures in upper epithelial layers.
- Dysplastic squamous epithelium extends into the endocervical glands. The latter are surrounded by a distinct basement membrane, which would be lacking in invasive carcinomas.
Atypias are found throughout all layers of the epithelium. Thus, this lesion is graded as an intraepithelial neoplasia grade III (CIN III)
Total excision of the carcinoma in situ by cervical conization is curative.