Histology Course A IV 35 Department of Pathology, University of Zurich Histokurs

A IV 35

Cavernous hemangioma of the liver and centrilobular necrosis HE further information (German) on HiPaKu 
  ICD-10: C22.0; ICD-O: 9120/0
66-year-old female succumbed to acute endocarditis with sepsis and right-sided cardiac failure (specimen from autopsy)
- Section of the liver showing a prominent, well-circumscribed tumor.
- The tumor consists of thin-walled, tightly packed vascular channels and intervening stroma. The vascular channels lined by endothelial cells are wide. Some are blood-filled, some show thrombosis.
- The tumor is not encapsulated.

- Outside of the tumor the hepatic tissue shows prominent congestion and extensive centrilobular necrosis (consequence of combined right- and left-sided cardiac failure; see also slide
A III 30)
Cavernous hemangiomas are the most common benign lesions of the liver. They are clinically not relevant, but have to be distinguished from metastatic tumors.