Histology Course A IV 33 Department of Pathology, University of Zurich Histokurs

A IV 33

leiomyosarcoma HE further information (German) on HiPaKu 
  ICD-10: C49.2; ICD-O: 8890/3
61-year-old male noticed a recently painful swelling of the right thigh. (Surgical specimen).
- A section of a skeletal muscle is shown containing in its center a circumscribed tumor.
- The tumor is composed of spindle cells exhibiting polymorphic nuclei with coarse chromatin. Some tumor cells contain grotesquely enlarged nuclei. Many mitoses are observed.
- Tumor shows a distinctly infiltrative growth pattern into the surrounding tissue. In addition, vascular invasion is observed.