Histology Course A IV 14 Department of Pathology, University of Zurich Histokurs

A IV 14 subacute thyroiditis HE further information (German) on HiPaKu 
  ICD-10: E06.1
46-year-old female suffered from sore throat and fever. A partial resection of the unilaterally enlarged thyroid gland was performed.
- In part, regular thyroid gland tissue exhibiting signs of increased stimulation. Adjacent parenchyma destroyed and partially scarred.
- A chronic inflammatory infiltrate is observed consisting of lymphocytes, plasma cells and histiocytes. The follicular epithelium is destroyed by invading lymphocytes.
- Formation of foreign body giant cell granulomas around colloid material. Some multinucleated giant cells contain ingested colloid material.
- Stromal fibrosis.

Usually, this type of thyroiditis only affects part of the gland. Therefore, hypothyroidism rarely ensues and most cases spontaneously resolve within a few months. The initial phase of the disease is frequently accompanied by hyperthyroidism (also compare: slide A IV 17).