Histology Course A IV 13 Department of Pathology, University of Zurich Histokurs

A IV 13 sarcoidosis, lymph node HE further information (German) on HiPaKu 
  ICD-10: D86.1
 
   
44-year-old female exhibited a painless enlargement of axillary and supraclavicular lymph nodes. Serum calcium levels were slightly increased above the normal range. An enlarged axillary lymph node was excised.
 
- The entire lymph node is permeated by non-caseating, partly confluent granulomas consisting of compact collections of epitheloid histiocytes that are on occasion, intermixed with multi-nucleated giant cells.
- Some granulomas exhibit a distinct fibrosis.

 
Per definition, sarcoidosis is a diagnosis of exclusion and other diseases causing a granulomatous reaction (e.g. tuberculosis) must be actively sought (acid-fast stain). Beware; tuberculosis may also produce non-caseating granulomas.