Histology Course A IV 12 Department of Pathology, University of Zurich Histokurs

A IV 12 foreign-body granuloma HE further information (German) on HiPaKu 
58-year-old male suffered from intervertebral disk disease (T12 - L1) with herniation of the disk 8 weeks before undergoing excision of the prolapsed disk (specimen from surgery).

- Synovial membrane with mixed inflammatory infiltrate consisting of lymphocytes, fibroblasts, plasma cells and histiocytes.
- In addition, numerous multinucleated giant cells are present containing in part birefringent, crystal-like foreign bodies. The latter are found ubiquitously in many of the synovial membrane fragments.

Pathogenesis: Foreign body granulomas are observed after traumas and surgeries (suture material, implants, vascular grafts and in earlier day’s talcum powder from gloves).