Histology Course A II 7 Department of Pathology, University of Zurich Histology Course

A II 7 cholestasis of the liver Sirius further information (German) on HiPaKu 
  ICD-10: K71.0
 
   
Male, 76 y., dies in cardiac shock after myocardial infarction
 
- green to dirty-brown-green, drop-shaped or branched inclusions between liver cells, so called bile thrombi
- the bile thrombi are predominantly located around the central veins
- concentrated bile in widened intercellular canaliculi: canalicular cholestasis
- bile drops in the cytoplasm of liver cells, occasionally in Kupffer cells: phagocytized bile
- hydropic swelling of sporadic liver cells or groups of liver cells with feathery degeneration of the cytoplasm: Cholate stasis probably caused by toxic bile acids (detergents)
- portal tracts enlarged, rounded, fibrosed, with ductal proliferation
- loose infiltration of the portal tracts by neutrophils and macrophages
- centrilobular necrosis of hepatocytes, caused by subacute passive congestion in heart failure