Histology Course A II 3 Department of Pathology, University of Zurich Histology Course

A II 3 Pneumonia secondary to obstructive lesion (lipid pneumonia) HE  
 
 
   
Male, 58 y., biopsy diagnosis: squamous cell carcinoma 3 years ago. autopsy material
 
- pathogenesis of lipid pneumonia: occlusion or stenosis of a bronchopulmonary segment due to an endobronchial tumor, mostl often a lung carcinoma. Blockade of secretion, retrostenotic expansion of bronchi, bacterial infection: neutrophils in the lumen of the bronchus
- phagocytosis of retained secretion and surfactant by alveolar macrophages: their cytoplasm is appearing bright, partially foamy
- few foreign-body giant cells
- alveolar septae partially thickened and fibrosed, focal lympho-histiocytic infiltrate
  
Gross findings:
Yellow "mantle" (lipid is yello, xanthos=yellow) of lung parenchyma around the tumor
 
Thorax X-ray: peritumoral shadow