Histology Course A II 17 Department of Pathology, University of Zurich Histology Course

A II 17 Corrosive injury to the stomach HE  
  ICD-10: T28
Female, 42 y., ingested concentrated hydrochloric acid in suicidal intent 8 days before death (section of the gastric wall from autopsy).
- A cross-section of the gastric wall is shown, - The mucosa is not any longer discernible. Instead, part of the submucosa is covered by a layer of debris consisting of necrotic cells, granulocytes, erythrocytes and fibrin. In part, the debris starts to dislodge from the underlying submucosa. - In the submucosa granulation tissue is present.
Ingestion of small amounts of concentrated hydrochlorid acid produces massive necrosis of the upper gastro-intestinal tract. A membrane consisting of the necrotic debris of the wall will form. Over time, the membrane will dislodge leading to perforation.