Histology Course A II 16 Department of Pathology, University of Zurich Histology Course

A II 16 acute myocardial infarction HE further information (German) on HiPaKu
  ICD-10: I21
(acute, transmural)
   
Male, 66 y., had a history of angina pectoris. He experienced prolonged chest pain radiating down the arm, cardiogenic shock ensued (specimen from autopsy).

- A transmural section of the left ventricle is shown.
- A vast, irregular area is observed with extensive coagulative necrosis of cardiomyocytes. The latter exhibit a homogenous hypereosinophilic cytoplasm and loss of nuclei. The necrosis is partly demarcated by an infiltrate of neutrophils.
- The visceral pericardium is infiltrated by inflammatory cells and covered by a layer of fibrin.
- A small subendocardial layer of viable cardiomyocytes is preserved, some displaying vacuolar degeneration.

Macroscopy:
atherosclerotic coronary artery obstruction with formation of an occlusive thrombus

Compare: slides A III 14, A IV 11