Histology Course A II 12 Department of Pathology, University of Zurich Histology Course

A II 12 Molluscum contagiosum HE further information (German) on HiPaKu 
  ICD-10: B08.1
 
   
8-year old boy exhibited small linearly arranged skin papules with central cores on hands and forearms. Of these white keratinous material could be expressed.
 
- Resection of the skin lesion shows not-affected skin to both sides.
- In the centre, a cup-shaped lesion is seen which consists of hyperplastic epidermis surrounding a central core. The latter opens towards the surface. The proliferating epidermis deeply indents the corium.
- 'Molluscum bodies': cells of stratum granulosum and corneum contain large, homogenous, basophilic cytoplasmatic inclusion bodies, the content of which ultimately empties into the cores (keratinous content of papules).
- Inclusion bodies consist of viral proteins.

 
The disease is contagious thus the name: M. 'contagiosum'.