Histology Course A II 11 Department of Pathology, University of Zurich Histology Course
A II 11 Acute viral hepatitis HE further information (German) on HiPaKu 
  ICD-10: B19
 
 

 
Female, 32 y., jaundice, fatigue, increased amino transferase and biliburin levels in the serum. Needle biopsy
 
- Intralobular and portal lymphohistiocytic infiltrate
- liver cells arranged in double-rows
- variable size of hepatocytes and of hepatocytic nuclei
- ballooned liver cells
- acidophil single cell necroses (apoptotic bodies=Councilman-bodies) frequently lacking a nucleus
- groups of pigmented macrophages indicating spotty necroses of liver parenchyma
 
Model of apoptotic cell death caused by immunologic, cytotoxic response of the organism after integration of viral antigens into the membrane of infected hepatocytes.