Histology Course A III 6 Department of Pathology, University of Zurich Histology Course

A III 6 Prostatic nodular hyperplasia HE further information (German) on HiPaKu 
  ICD-10: N40
68-year-old male underwent suprapubic prostatectomy because of urinary retention and dysuria.
- Increased number of partly dilated glands that are lined by pale epithelial cells. Papillary infoldings are frequent (hyperplasia of the glandular compartment).
- Stromal proliferation with hyperplasia of smooth muscle cells and connective tissue, leading in part to formation of nodules.
- Focal inflammatory infiltrates.

Hyperplasia originates in the inner part of the gland (portions around urethra), sparing the outer gland (which is also known as the surgical capsule).
Complications: Obstruction of urethra, dysuria, urinary retention.
Differential diagnosis: Carcinoma of the prostate
(A IV 49)
Macroscopy: Enlarged prostate with an elastic to firm consistency. Formation of nodules.